Expressive

rs12023742 - PLA2G2E - RN7SL304P

Magnitude 2.2 · 2 studies on file

Reported associations

  • Group IIA Secretory Phospholipase A2 and Incident Cardiovascular Disease: An Analysis from the JUPITER Trial - Unknown journal (n.d.) · Unknown authors · PubMed 31070471

    ABSTRACT: Objectives: Inflammation is a causal risk factor for cardiovascular disease (CVD). Group IIA secretory phospholipase A2 (sPLA2-IIA) plays an integral role in regulating vascular inflammation. While studies investigated sPLA2-IIA in secondary prevention, we prospectively evaluated sPLA2-IIA mass and genetic variants with CVD events in a primary prevention population with chronic inflammation. Approach and Results: The JUPITER trial (NCT00239681) randomized participants with LDLc <130 mg/dL and hsCRP ≥2 mg/L to high-intensity rosuvastatin vs placebo. Baseline and 1-year plasma sPLA2-IIA mass was measured (N=11,269 baseline; N=9,620 1-year). We also identified genetic variants influencing sPLA2-IIA using genome-wide association and examined them with CVD. 313 incident CVD events o

  • Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations - Unknown journal (n.d.) · Unknown authors · PubMed 36168886

    ABSTRACT: Abstract Polygenic scores (PGS) can identify individuals at risk of adverse health events and guide genetics-based personalized medicine. However, it is not clear how well PGS translate between different populations, limiting their application to well-studied ethnicities. Proteins are intermediate traits linking genetic predisposition and environmental factors to disease, with numerous blood circulating protein levels representing functional readouts of disease-related processes. We hypothesized that studying the genetic architecture of a comprehensive set of blood-circulating proteins between a European and an Arab population could shed fresh light on the translatability of PGS to understudied populations. We therefore conducted a genome-wide association study with whole-genome

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