rs1202179 - ABCB1

Magnitude 4.5 · 1 study on file

Reported associations

• Association Between ABCB1 Genetic Variants and Persistent Chemotherapy-Induced Alopecia in Women With Breast Cancer. - JAMA dermatology (2021) · Núñez-Torres R, Martín M, García-Sáenz JÁ, Rodrigo-Faus M, Del Monte-Millán M, Tejera-Pérez H, Pita G, de la Torre-Montero JC, Pinilla K, Herraez B, Peiró-Chova L, Bermejo B, Lluch A, González-Neira A · PubMed 32756886

  Persistent chemotherapy-induced alopecia (pCIA) has been recently described in patients with breast cancer and in its most severe form occurs in up to 10% of these patients. Genetic risk factors associated with pCIA have not been adequately explored. To identify genetic variants associated with pCIA. In this genetic association study, 215 women with breast cancer treated with docetaxel-based chemotherapy with a follow-up of 1.5 to 10 years after the end of the treatment were recruited retrospectively through 3 hospital oncology units across Spain between 2005 and 2018. Severe pCIA was defined as lack of scalp hair recovery (Common Terminology Criteria for Adverse Events, version 3.0, grade 2) 18 months or more after the end of treatment. Patients with grade 2 pCIA were selected as cases, a

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.