Expressive

rs12019546 - MCF2L

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease - Unknown journal (n.d.) · Unknown authors · PubMed 29212778

    ABSTRACT: Supplemental Digital Content is available in the text. Rationale: Coronary artery disease (CAD) is a complex phenotype driven by genetic and environmental factors. Ninety-seven genetic risk loci have been identified to date, but the identification of additional susceptibility loci might be important to enhance our understanding of the genetic architecture of CAD. Objective: To expand the number of genome-wide significant loci, catalog functional insights, and enhance our understanding of the genetic architecture of CAD. Methods and Results: We performed a genome-wide association study in 34 541 CAD cases and 261 984 controls of UK Biobank resource followed by replication in 88 192 cases and 162 544 controls from CARDIoGRAMplusC4D. We identified 75 loci that replicated and

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • lipid panel Moderate

    Lipid profile monitoring is essential for CAD risk stratification in risk allele carriers

    baseline lipid panel, repeat every 4-5 years or per physician recommendation

Diet

  • Mediterranean or DASH diet pattern Moderate

    Heart-healthy diet patterns reduce CAD risk in those with genetic predisposition

    emphasize vegetables, fruits, whole grains, legumes, fish, limit saturated fat

Discuss with your doctor

  • CAD screening strategy and intensity Moderate

    rs12019546-A increases CAD risk; individualized prevention strategy may be indicated

    discuss appropriate timing and intensity of CAD screening with your physician

Exercise

  • regular aerobic exercise Moderate

    Exercise reduces CAD risk; variant carriers have increased baseline risk

    150 minutes moderate-intensity aerobic activity per week

Screening

  • cardiovascular risk assessment Moderate

    rs12019546-A is associated with increased coronary artery disease risk in large cohort

    baseline lipid panel, blood pressure screening, EKG based on age and risk profile