rs12010175 - CCNQ
Magnitude 2.8 · 1 study on file
Reported associations
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A Genome-Wide Association Study Identifies GRK5 and RASGRP1 as Type 2 Diabetes Loci in Chinese Hans - Unknown journal (n.d.) · Unknown authors · PubMed 22961080
ABSTRACT: Substantial progress has been made in identification of type 2 diabetes (T2D) risk loci in the past few years, but our understanding of the genetic basis of T2D in ethnically diverse populations remains limited. We performed a genome-wide association study and a replication study in Chinese Hans comprising 8,569 T2D case subjects and 8,923 control subjects in total, from which 10 single nucleotide polymorphisms were selected for further follow-up in a de novo replication sample of 3,410 T2D case and 3,412 control subjects and an in silico replication sample of 6,952 T2D case and 11,865 control subjects. Besides confirming seven established T2D loci (CDKAL1, CDKN2A/B, KCNQ1, CDC123, GLIS3, HNF1B, and DUSP9) at genome-wide significance, we identified two novel T2D loci, including G
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic risk factor for type 2 diabetes Moderate
Carries rs12010175 G allele, identified in GWAS of 3,712 participants with 1.21-fold elevated T2D risk
Review this genetic finding and coordinate diabetes prevention strategy with other metabolic risk factors
Screening
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Type 2 diabetes screening frequency Moderate
rs12010175 risk allele G increases Type 2 diabetes susceptibility 1.21-fold independent of BMI
Discuss with healthcare provider whether to begin screening earlier or increase screening frequency