rs11997465 - U2 - KCNV1

Magnitude 2.8 · 1 study on file

Reported associations

• Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans - Unknown journal (n.d.) · Unknown authors · PubMed 31092297

  ABSTRACT: Background End-stage kidney disease (ESKD) is a significant public health concern disproportionately affecting African Americans (AAs). Type 2 diabetes (T2D) is the leading cause of ESKD in the USA, and efforts to uncover genetic susceptibility to diabetic kidney disease (DKD) have had limited success. A prior genome-wide association study (GWAS) in AAs with T2D-ESKD was expanded with additional AA cases and controls and genotypes imputed to the higher density 1000 Genomes reference panel. The discovery analysis included 3432 T2D-ESKD cases and 6977 non-diabetic non-nephropathy controls (N = 10,409), followed by a discrimination analysis in 2756 T2D non-nephropathy controls to exclude T2D-associated variants. Results Six independent variants located in or near RND3/RBM43, SLI

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