rs11997254 - TRAPPC9
Magnitude 2.2 · 1 study on file
Reported associations
-
High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941
ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
-
DASH diet or sodium restriction Moderate
T allele is associated with higher systolic blood pressure; DASH diet and sodium restriction are proven BP interventions
Adopt DASH diet principles; limit sodium to less than 2300 mg daily
Exercise
-
regular aerobic exercise for blood pressure management Moderate
T allele is associated with higher systolic blood pressure; aerobic exercise is a proven BP intervention
150 minutes moderate aerobic exercise weekly or 75 minutes vigorous weekly
Screening
-
blood pressure monitoring Moderate
T allele is associated with higher systolic blood pressure; monitoring helps detect and manage this increased risk
Check blood pressure monthly or as recommended by doctor