Expressive

rs11995244 - MFHAS1

Magnitude 2.8 · 1 study on file

Reported associations

  • A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness - Unknown journal (n.d.) · Unknown authors · PubMed 32152699

    ABSTRACT: Gastrointestinal infections can be life threatening, but not much is known about the host's genetic contribution to susceptibility to gastrointestinal infections or the latter's association with psychiatric disorders. We utilized iPSYCH, a genotyped population-based sample of individuals born between 1981 and 2005 comprising 65,534 unrelated Danish individuals (45,889 diagnosed with mental disorders and 19,645 controls from a random population sample) in which all individuals were linked utilizing nationwide population-based registers to estimate the genetic contribution to susceptibility to gastrointestinal infections, identify genetic variants associated with gastrointestinal infections, and examine the link between gastrointestinal infections and psychiatric and neurodev

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • gastrointestinal infection prevention Moderate

    Genetic susceptibility to GI infection suggests personalized prevention approach may reduce infection risk

    Discuss handwashing, food safety, water precautions, and travel-related infection prevention

Lifestyle

  • enhanced food and water safety practices Moderate

    Higher GI infection susceptibility suggests greater benefit from contamination prevention

    Practice rigorous handwashing before eating, cook meats to safe temperatures, avoid untreated water

Screening

  • gastrointestinal infection symptoms Moderate

    T allele at rs11995244 is associated with 1.37-fold increased susceptibility to gastrointestinal infection

    Monitor for diarrhea, nausea, vomiting, abdominal pain; seek care if symptoms persist more than 48 hours