Expressive

rs11993596 - LINC03042

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-Wide Association Study of Erosive Tooth Wear in a Finnish Cohort. - Caries research (2019) · Alaraudanjoki VK, Koivisto S, Pesonen P, Männikkö M, Leinonen J, Tjäderhane L, Laitala ML, Lussi A, Anttonen VA · PubMed 29898447

    Erosive tooth wear is defined as irreversible loss of dental tissues due to intrinsic or extrinsic acids, exacerbated by mechanical forces. Recent studies have suggested a higher prevalence of erosive tooth wear in males, as well as a genetic contribution to susceptibility to erosive tooth wear. Our aim was to examine erosive tooth wear by performing a genome-wide association study (GWAS) in a sample of the Northern Finland Birth Cohort 1966 (n = 1,962). Erosive tooth wear was assessed clinically using the basic erosive wear examination. A GWAS was performed for the whole sample as well as separately for males and females. We identified one genome-wide significant signal (rs11681214) in the GWAS of the whole sample near the genes PXDN and MYT1L. When the sample was stratified by sex, the s

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • High-acid beverages and foods Moderate

    Acidic foods and beverages are primary drivers of dental erosion; genetic predisposition increases risk when exposed to dietary acids.

    Limit cola, wine, citrus juices, sports drinks; rinse mouth with water after consumption

Lifestyle

  • Protective oral care practices Moderate

    Gentle oral hygiene and mechanical protection reduce erosion risk in genetically susceptible individuals.

    Use soft toothbrush, avoid aggressive brushing, consider protective mouthguard if high-risk activities

Screening

  • Increased dental screening for erosive tooth wear Moderate

    Genetic variant rs11993596 is associated with increased susceptibility to severe erosive tooth wear; earlier detection enables preventive intervention.

    Biannual or more frequent dental examinations with specific assessment for erosive wear