rs11992528 - LINC01299

Magnitude 2.0 · 1 study on file

Reported associations

• Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status - Behavior genetics (2022) · Pasman JA, Demange PA, Guloksuz S, Willemsen AHM, Abdellaoui A, Ten Have M, Hottenga JJ, Boomsma DI, de Geus E, Bartels M, de Graaf R, Verweij KJH, Smit DJ, Nivard M, Vink JM · PubMed 34855049

  ABSTRACT: This study aims to disentangle the contribution of genetic liability, educational attainment (EA), and their overlap and interaction in lifetime smoking. We conducted genome-wide association studies (GWASs) in UK Biobank (N = 394,718) to (i) capture variants for lifetime smoking, (ii) variants for EA, and (iii) variants that contribute to lifetime smoking independently from EA ('smoking-without-EA'). Based on the GWASs, three polygenic scores (PGSs) were created for individuals from the Netherlands Twin Register (NTR, N = 17,805) and the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2, N = 3090). We tested gene-environment (G × E) interactions between each PGS, neighborhood socioeconomic status (SES) and EA on lifetime smoking. To assess i

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