rs11990607 - RNU6-1213P - Y_RNA
Magnitude 2.2 · 1 study on file
Reported associations
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A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio - Unknown journal (n.d.) · Unknown authors · PubMed 31630189
ABSTRACT: Abstract Raised albumin-creatinine ratio (ACR) is an indicator of microvascular damage and renal disease. We aimed to identify genetic variants associated with raised ACR and study the implications of carrying multiple ACR-raising alleles with metabolic and vascular-related disease. We performed a genome-wide association study of ACR using 437 027 individuals from the UK Biobank in the discovery phase, 54 527 more than previous studies, and followed up our findings in independent studies. We identified 62 independent associations with ACR across 56 loci (P < 5 × 10-8), of which 20 were not previously reported. Pathway analyses and the identification of 20 of the 62 variants (at r2 > 0.8) coinciding with signals for at least 16 related metabolic and vascular t
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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urine albumin-to-creatinine ratio baseline testing Moderate
The rs11990607 A allele is associated with higher urinary albumin-to-creatinine ratio, a kidney health biomarker linked to cardiovascular disease risk.
Obtain ACR testing to establish baseline kidney function status