rs11990550 - XKR6

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study identifies TPH2 variant as a novel locus for severe CV-A6-associated hand, foot, and mouth disease in Han Chinese. - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (2020) · Meng Y, Xiong T, Zhao R, Liu J, Yu G, Xiao J, Wang K, Wu T, Fu W, Guo H, Huang J, Wei S · PubMed 32634583

  Little is known about the association between genetic susceptibility and the severity of hand, foot, and mouth disease (HFMD) infected with coxsackievirus A6 (CV-A6). Three hundred and sixty-four CV-A6 HFMD patients were enrolled, including 115 severe and 249 mild patients. A genome-wide association study (GWAS) was performed involving eight DNA pools of 115 severe and 115 mild CV-A6 HFMD patients pair-matched by age and gender. Differences in relative allele signal scores of SNPs in Illumina Human OmniZhongHua-8 BeadChips were compared between the two groups. The tag SNPS for potentially functional SNPs or their high linked SNPs were selected for individual genotyping in all 364 patients and assessed for their associations with severe CV-A6 HFMD using multivariable logistic regression ana

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