rs1199015110 - SPATA31A1

Magnitude 2.0 · 1 study on file

Reported associations

• Genetic predisposition to tinnitus in the UK Biobank population - Scientific reports (2021) · Urbanek ME, Zuo J · PubMed 34518561

  ABSTRACT: Tinnitus, the phantom perception of noise originating from the inner ear, has been reported by 15% of the world's population, with many patients reporting major deficits to cognition and mood. However, both objective diagnostic tools and targeted therapeutic strategies have yet to be established. To better understand the underlying genes that may preclude tinnitus, we performed a genome-wide association study of the UK Biobank's 49,960 whole exome sequencing participants to identify any loci strongly associated with tinnitus. We identified 17 suggestive single nucleotide polymorphisms (p < 1e−5) spanning 13 genes in two sex-separated cohorts reporting chronic, bothersome tinnitus (control males n = 7,315, tinnitus males n = 226, control females n = 11,732, t

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