rs1198929434 - IQCJ-SCHIP1, SCHIP1

Magnitude 2.2 · 1 study on file

Reported associations

• Elevated body mass index is associated with an increased risk of infectious disease admissions and mortality: a mendelian randomization study. - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases (2025) · Butler-Laporte G, Harroud A, Forgetta V, Richards JB · PubMed 32592749

  The effect of body mass index (BMI) on the risk of infectious diseases admissions and mortality is unclear and is difficult to study given the risks of confounding variables. We used genome-wide association studies (GWASs) with mendelian randomization (MR) to obtain causal inference of BMI on the following infectious diseases outcomes: hospital admissions for pneumonia, sepsis, urinary tract infections, skin and soft tissue infections (SSTIs) or all-cause infections. For patients with pneumonia and sepsis, we also analysed their 28-day and 90-day mortalities. The UK Biobank (UKB) cohort (n > 500 000) provided data for GWASs on infectious diseases. The GIANT consortium (n = 681 265) GWAS was used to identify single-nucleotide polymorphisms (SNPs) associated with BMI. Genetically incre

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