rs11986935 - PINX1, PINX1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota - Unknown journal (n.d.) · Unknown authors · PubMed 27723756

  ABSTRACT: Human gut microbiota is an important determinant for health and disease, and recent studies emphasize the numerous factors shaping its diversity. Here we performed a genome-wide association study (GWAS) of the gut microbiota using two cohorts from northern Germany totaling 1,812 individuals. Comprehensively controlling for diet and non-genetic parameters, we identify genome-wide significant associations for overall microbial variation and individual taxa at multiple genetic loci, including the VDR gene (encoding vitamin D receptor). We observe significant shifts in the microbiota of Vdr−/− mice relative to control mice and correlations between the microbiota and serum measurements of selected bile and fatty acids in humans, including known ligands and downstream metabolites o

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