rs11984688 - PXDNL
Magnitude 2.2 · 1 study on file
Reported associations
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GWAS for primary angle-closure glaucoma identifies loci related to ocular biometry and morphology - Unknown journal (n.d.) · Unknown authors · PubMed 41238566
ABSTRACT: GWAS of primary angle-closure glaucoma have identified eight loci conferring risk in Asian populations. However, it remains unclear whether the genetic risk factors for the disease are consistent across different populations. Here, we present a discovery GWAS for primary angle-closure glaucoma in Europeans using the UK Biobank. We replicate our findings in six independent European populations and compare these results with results from 14 Asian cohorts. Five genomic regions in the discovery cohort are associated at genome-wide significance, including two loci previously identified in Asian cohorts. We next meta-analyse the discovery and replication cohorts to identify six additional novel loci, all previously associated with refractive error. Mendelian randomisation provides evid
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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angle-closure glaucoma screening Moderate
rs11984688 C allele increases risk for primary angle-closure glaucoma, a potentially blinding condition often undiagnosed until vision loss occurs
Schedule eye examination with gonioscopy; discuss screening intervals and risk factors with ophthalmologist