rs11983228 - BRAF - CCT4P1
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation - Unknown journal (n.d.) · Unknown authors · PubMed 35551307
ABSTRACT: We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent) through the DIAMANTE (DIAbetes Meta-ANalysis of Trans-Ethnic association studies) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10−9), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular me
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Type 2 diabetes prevention strategy Moderate
C allele carriers have elevated genetic risk for Type 2 diabetes, warranting personalized assessment and preventive planning with a healthcare provider.
- GWAS_CATALOG:35551307
Screening
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Type 2 diabetes screening with HbA1c Moderate
The C allele at rs11983228 confers increased Type 2 diabetes risk in large population studies, warranting heightened surveillance in carriers.
HbA1c and fasting glucose testing every 1-2 years starting at age 30; annual screening if overweight or obese
- GWAS_CATALOG:35551307