Expressive

rs11976775 - TNPO3

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827

    ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • limit refined carbohydrates and added sugars Moderate

    Refined carbohydrates and added sugars elevate triglycerides, particularly relevant for genetically predisposed individuals

    Replace refined grains with whole grains; limit added sugars to <25g daily

    • GWAS_CATALOG:40436827

Exercise

  • aerobic exercise Moderate

    Regular aerobic exercise reduces triglyceride levels and cardiovascular risk

    Aim for 150 minutes of moderate aerobic activity per week

    • GWAS_CATALOG:40436827

Screening

  • triglyceride levels Moderate

    rs11976775 in TNPO3 is associated with higher triglyceride levels increasing cardiovascular risk

    Check lipid panel annually or every 2 years, more frequently if levels are elevated

    • GWAS_CATALOG:40436827