rs11976006 - CREB5
Magnitude 2.2 · 1 study on file
Reported associations
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GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network - Unknown journal (n.d.) · Unknown authors · PubMed 31311600
ABSTRACT: Background Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with a genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pathogenesis and progression of NAFLD is complex with many unanswered questions. We conducted genome-wide association studies (GWASs) using both adult and pediatric participants from the Electronic Medical Records and Genomics (eMERGE) Network to identify novel genetic contributors to this condition. Methods First, a natural language processing (NLP) algorithm was developed, tested, and deployed at each site to identify 1106 NAFLD cases and 8571 controls and histological data from liver tissue in 235 available participants. These include 1242 pediatric participants
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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liver function panel (ALT, AST) Moderate
A allele at rs11976006 is associated with elevated alanine aminotransferase in non-alcoholic fatty liver disease, indicating altered hepatic function
annual or biennial testing