rs11971943 - CNTNAP2

Magnitude 2.2 · 1 study on file

Reported associations

• Association analyses of the autosomal genome and mitochondrial DNA with accelerometry-derived sleep parameters in depressed UK biobank subjects. - Journal of psychiatric research (2023) · Melhuish Beaupre LM, Wainberg M, Zai CC, Milic M, Felsky D, Brown G, Goldstein BI, Tripathy SJ, Kennedy JL, Gonçalves VF · PubMed 36463630

  The bidirectional relationship between sleep disturbances and depression is well documented, yet the biology of sleep is not fully understood. Mitochondria have become of interest not only because of the connection between sleep and metabolism but also because of mitochondria's involvement in the production of reactive oxygen species, which are largely scavenged during sleep. Genome-wide association studies (GWAS) of eight accelerometry-derived sleep measures were performed across both the autosomal and mitochondrial DNA (mtDNA) among two severity levels of depression in UK Biobank participants. We calculated SNP heritability for each of the sleep measures. Linear regression was performed to test associations and mitochondrial haplogroups. Variants included in the GWAS accounted for modera

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