rs11962123 - NPM1P10 - HACE1

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic analysis in African American children supports ancestry specific neuroblastoma susceptibility - Unknown journal (n.d.) · Unknown authors · PubMed 35131881

  ABSTRACT: Background. Neuroblastoma is rarer in African American (AA) children compared to American children of European descent. AA children affected with neuroblastoma, however, more frequently develop the high-risk form of the disease. Methods. We have genotyped an AA cohort of 629 neuroblastoma cases (254 high-risk) and 2,990 controls to investigate genetic susceptibility to neuroblastoma in AAs. Results. We confirmed the known neuroblastoma susceptibility gene BARD1 at genome-wide significance in the subset of high-risk cases. We also estimated local admixture across the autosomal genome in the AA cases and controls and detected a signal at 4q31.22 where cases show an increase in European ancestry. A region at 17p13.1 showed increased African ancestry in the subgroup of high-risk case

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