rs11962089 - POPDC1-AS1, POPDC3

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study of severity in multiple sclerosis - Unknown journal (n.d.) · Unknown authors · PubMed 21654844

  ABSTRACT: Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system with a strong genetic component. Several lines of evidence support a strong role for genetic factors influencing both disease susceptibility and clinical outcome in MS. Identification of genetic variants that distinguish particular disease subgroups and/or predict a severe clinical outcome is critical to further our understanding of disease mechanisms and guide development of effective therapeutic approaches. We studied 1470 MS cases and performed a genome-wide association study of more than 2.5 million single-nucleotide polymorphisms to identify loci influencing disease severity, measured using the MS severity score (MSSS), a measure of clinical disability. Of note, no single result achieved

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