rs1195935 - ADGRD1

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic associations with immune-mediated outcomes after allogeneic hematopoietic cell transplantation - Unknown journal (n.d.) · Unknown authors · PubMed 34996099

  ABSTRACT: Key Points A recipient variant correlated with DPB1 expression is associated with the risks of GVHD and relapse after unrelated HCT. Larger cohorts would be needed to detect other genotypic associations with aGVHD, cGVHD, and relapse after allogeneic HCT. Visual Abstract Abstract Previous studies have identified more than 200 genetic variants associated with acute or chronic graft-versus-host disease (aGVHD; cGVHD) or recurrent malignancy after allogeneic hematopoietic cell transplantation (HCT). We tested these candidate donor and recipient variants in a cohort of 4270 HCT recipients of European ancestry and in subcohorts of 1827 sibling and 1447 unrelated recipients who had 10/10 HLA-A, B, C, DRB1, and DQB1-matched donors. We also carried out a genome-wide association study (GW

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