rs11957368 - MARK2P11 - LINC02227

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-Wide Association Study of a Heart Failure-Related Metabolomic Profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) Study - Unknown journal (n.d.) · Unknown authors · PubMed 23934736

  ABSTRACT: Both the prevalence and incidence of heart failure (HF) are increasing, especially among African-Americans, but no large-scale, genome-wide association study (GWAS) of HF-related metabolites have been reported. We sought to identify novel genetic variants that are associated with metabolites previously reported to relate to HF incidence. GWASs of three metabolites identified previously as risk factors for incident HF (pyroglutamine, dihydroxy docosatrienoic acid and X-11787, being either hydroxy-leucine or hydroxy-isoleucine) were performed in 1260 African-Americans free of HF at the baseline examination of the Atherosclerosis Risk in Communities (ARIC) study. A significant association on chromosome 5q33 (rs10463316, MAF = 0.358, p-value = 1.92×10−10) was identified for pyrogl

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.