rs11957260 - ANKRD31 - HMGCR
Magnitude 2.2 · 1 study on file
Reported associations
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A genome-wide search for gene-by-obesity interaction loci of dyslipidemia in Koreans shows diverse genetic risk alleles. - Journal of lipid research (2020) · Kang M, Sung J · PubMed 31662442
Dyslipidemia is a well-established risk factor for CVD. Studies suggest that similar fat accumulation in a given population might result in different levels of dyslipidemia risk among individuals; for example, despite similar or leaner body composition compared with Caucasians, Asians of Korean descent experience a higher prevalence of dyslipidemia. These variations imply a possible role of gene-obesity interactions on lipid profiles. Genome-wide association studies have identified more than 500 loci regulating plasma lipids, but the interaction structure between genes and obesity traits remains unclear. We hypothesized that some loci modify the effects of obesity on dyslipidemia risk and analyzed extensive gene-environment interactions (G×Es) at genome-wide levels to search for replicate
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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LDL cholesterol level Moderate
rs11957260 is associated with LDL cholesterol levels; HMGCR encodes rate-limiting enzyme for cholesterol synthesis
Baseline lipid panel and every 1-3 years; more frequently if initiating or adjusting statin therapy
Discuss with your doctor
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Statin therapy and cardiovascular risk assessment Moderate
Genetic elevation of LDL is a major risk factor for atherosclerotic cardiovascular disease; HMGCR variation may influence statin response
Discuss 10-year ASCVD risk score and statin therapy candidacy based on your overall health status