rs11955068 - CEP72-DT

Magnitude 2.0 · 1 study on file

Reported associations

• Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma - Unknown journal (n.d.) · Unknown authors · PubMed 32918910

  ABSTRACT: BACKGROUND & AIMS: Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophagus (BE), are characterized by a strong and yet unexplained male predominance (with a male-to-female ratio in EA incidence of up to 6:1). Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci for these conditions. However, potential sex differences in genetic associations with BE/EA remain largely unexplored. METHODS: Given strong genetic overlap, BE and EA cases were combined into a single case group for analysis. These were compared with population-based controls. We performed sex-specific GWAS of BE/EA in 3 separate studies and then used fixed-effects meta-analysis to provide summary estimates for >9 million variants for male and female individuals

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