rs11955050 - LINC01957 - TRIM36
Magnitude 2.2 · 1 study on file
Reported associations
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High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941
ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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DASH dietary pattern Moderate
DASH diet reduces systolic blood pressure; beneficial for carriers of genetic BP-raising variant
emphasize vegetables, fruits, whole grains, lean proteins; limit sodium to <2300 mg daily
Exercise
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regular aerobic exercise Moderate
Aerobic activity reduces systolic blood pressure; beneficial for carriers of genetic BP-raising variant
150 minutes weekly of moderate-intensity aerobic exercise
Screening
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systolic blood pressure Moderate
rs11955050 associates with elevated systolic blood pressure in large GWAS cohort (n=526001, p=2e-11)
baseline measurement by age 25, annual monitoring thereafter