rs11954639 - TTC33

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-Wide Association Scan of Serum Urea in European Populations Identifies Two Novel Loci. - American journal of nephrology (2020) · Thio CHL, Reznichenko A, van der Most PJ, Kamali Z, Vaez A, Smit JH, Penninx BWJH, Haller T, Mihailov E, Metspalu A, Damman J, de Borst MH, van der Harst P, Verweij N, Navis GJ, Gansevoort RT, Nolte IM, Snieder H · PubMed 30808845

  Serum urea level is a heritable trait, commonly used as a diagnostic marker for kidney function. Genome-wide association studies (GWAS) in East-Asian populations identified a number of genetic loci related to serum urea, however there is a paucity of data for European populations. We performed a two-stage meta-analysis of GWASs on serum urea in 13,312 participants, with independent replication in 7,379 participants of European ancestry. We identified 6 genome-wide significant single nucleotide polymorphisms (SNPs) in or near 6 loci, of which 2 were novel (POU2AF1 and ADAMTS9-AS2). Replication of East-Asian and Scottish data provided evidence for an additional 8 loci. SNPs tag regions previously associated with anthropometric traits, serum magnesium, and urinary albumin-to-creatinine ratio,

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