rs11954381 - RPSAP37 - LINC02039

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-Wide Analysis of Sex Disparities in the Genetic Architecture of Lung and Colorectal Cancers - Unknown journal (n.d.) · Unknown authors · PubMed 34062886

  ABSTRACT: Almost all complex disorders have manifested epidemiological and clinical sex disparities which might partially arise from sex-specific genetic mechanisms. Addressing such differences can be important from a precision medicine perspective which aims to make medical interventions more personalized and effective. We investigated sex-specific genetic associations with colorectal (CRCa) and lung (LCa) cancers using genome-wide single-nucleotide polymorphisms (SNPs) data from three independent datasets. The genome-wide association analyses revealed that 33 SNPs were associated with CRCa/LCa at P < 5.0 × 10−6 neither males or females. Of these, 26 SNPs had sex-specific effects as their effect sizes were statistically different between the two sexes at a Bonferroni-adjusted significa

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