rs11954020 - IL7R - CAPSL

Magnitude 2.2 · 1 study on file

Reported associations

• Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers - Unknown journal (n.d.) · Unknown authors · PubMed 25751624

  ABSTRACT: Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions (www.T1DBase.org) revealing major pathways contributing to risk, with some loci shared across immune disorders. In order to make genetic comparisons across autoimmune disorders as informative as possible a dense genotyping array, the ImmunoChip, was developed, from which four novel T1D regions were identified (P < 5 × 10−8). A comparative analysis with 15 immune diseases (www.ImmunoBase.org) revealed that T1D is more similar genetically to other autoantibody-positive diseases, most significantly to juvenile idiopathic arthritis and least to ulcerative colitis, and provided support for three additional novel T1D loci. Using a Bayesian approach, we defined credible sets for the T1D SNPs. These T1D

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