Expressive

rs11951673 - CAST, CAST

Magnitude 2.2 · 2 studies on file

Reported associations

  • Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 30239722

    ABSTRACT: Abstract More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, are more informative for predicting risk of obesity sequelae, including cardiometabolic disease and cancer. We performed a genome-wide association study meta-analysis of body fat distribution, measured by waist-to-hip ratio (WHR) adjusted for body mass index (WHRadjBMI), and identified 463 signals in 346 loci. Heritability and variant effects were generally stronger in women than men, and we found approximately one-third of all signals to be sexually dimorphic. The 5% of individuals carrying the most WHRadjBMI-increasing alleles were 1.62 times more likely than the bottom 5% to have a WHR

  • Trans-Ethnic Analysis of Metabochip Data Identifies Two New Loci Associated with BMI - Unknown journal (n.d.) · Unknown authors · PubMed 29381148

    ABSTRACT: Objective Body mass index (BMI) is commonly used to assess obesity, which is associated with numerous diseases and negative health outcomes. BMI has been shown to be a heritable, polygenic trait, with close to 100 loci previously identified and replicated in multiple populations. We aim to replicate known BMI loci and identify novel associations in a trans-ethnic study population. Subjects Using eligible participants from the Population Architecture using Genomics and Epidemiology (PAGE) consortium, we conducted a trans-ethnic meta-analysis of 102,514 African Americans, Hispanics, Asian/Native Hawaiian, Native Americans and European Americans. Participants were genotyped on over 200,000 SNPs on the Illumina Metabochip custom array, or imputed into the 1000 Genomes Project (Phase

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