Expressive

rs11951625 - PDCD6, PDCD6-AHRR

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827

    ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic predisposition to weight gain Moderate

    rs11951625 T allele is associated with increased body weight; clinical guidance enables personalized prevention strategy

    Discuss variant and weight management strategy with primary care provider

Exercise

  • regular aerobic and resistance exercise Moderate

    Physical activity mitigates genetic predisposition to weight accumulation through energy expenditure and metabolic optimization

    150 minutes moderate aerobic activity weekly; resistance training 2-3 days per week

Lifestyle

  • mindful eating and portion control Moderate

    Behavioral strategies support weight management by reinforcing caloric balance despite genetic predisposition

    Practice mindful eating; use portion control techniques; minimize distracted eating

Screening

  • weight and BMI Moderate

    rs11951625 T allele associates with elevated body weight (GWAS p=1.00e-14, effect=0.042, n=928679)

    Track weight and BMI at routine medical visits or semi-annually