rs11951031 - MEF2C

Magnitude 2.2 · 1 study on file

Reported associations

• Meta-Analysis of Genome-Wide Studies Identifies MEF2C SNPs Associated with Bone Mineral Density at Forearm - Unknown journal (n.d.) · Unknown authors · PubMed 23572186

  ABSTRACT: Background Forearm fractures affect 1.7 million individuals worldwide each year and most occur earlier in life than hip fractures. While the heritability of forearm bone mineral density (BMD) and fracture is high, their genetic determinants are largely unknown. Aim To identify genetic variants associated with forearm BMD and forearm fractures. Methods BMD at distal radius measured by dual-energy X-ray absorptiometry was tested for association with common genetic variants. We conducted a meta-analysis of genome-wide association studies for BMD in 5,866 subjects of European descent and then selected variants for replication in 715 Mexican American samples. Gene-based association was carried out to supplement the single-SNP test. We then tested the BMD-associated SNPs for associatio

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