rs11950494 - ACTBL2, RMEL3

Magnitude 4.5 · 1 study on file

Reported associations

• Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure - Unknown journal (n.d.) · Unknown authors · PubMed 28738859

  ABSTRACT: Background Studies aiming to assess genetic susceptibility for impaired lung function levels upon exposure to environmental tobacco smoke (ETS) have thus far focused on candidate-genes selected based on a-priori knowledge of potentially relevant biological pathways, such as glutathione S-transferases and ADAM33. By using a hypothesis-free approach, we aimed to identify novel susceptibility loci, and additionally explored biological pathways potentially underlying this susceptibility to impaired lung function in the context of ETS exposure. Methods Genome-wide interactions of single nucleotide polymorphism (SNP) by ETS exposure (0 versus ≥1 h/day) in relation to the level of forced expiratory volume in one second (FEV1) were investigated in 10,817 subjects from the Dutch LifeLi

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