rs11950 - TRAM2-AS1 - TMEM14A

Magnitude 2.2 · 1 study on file

Reported associations

• The influence of regression models on genome-wide association studies of alcohol dependence: a comparison of binary and quantitative analyses. - Psychiatric genetics (2021) · Li W, Thygesen JH, O'Brien NL, Heydtmann M, Smith I, Degenhardt F, Nöthen MM, Morgan MY, Bass NJ, McQuillin A · PubMed 33290381

  Genome-wide association studies (GWAS) of alcohol dependence syndrome (ADS) offer a platform to detect genetic risk loci. However, the majority of the ADS GWAS undertaken, to date, have utilized a case-control design and have failed to identify consistently replicable loci with the exception of protective variants within the alcohol metabolizing genes, notably ADH1B. The ADS phenotype shows considerable variability which means that the use of quantitative variables as a proxy for the severity of ADS has the potential to facilitate identification of risk loci by increasing statistical power. The current study aims to examine the influences of using binary and adjusted quantitative measures of ADS on GWAS outcomes and on calculated polygenic risk scores (PRS). A GWAS was performed in 1251 he

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