rs11948853 - PRELID2

Magnitude 2.2 · 1 study on file

Reported associations

• A reference map of potential determinants for the human serum metabolome. - Nature (2021) · Bar N, Korem T, Weissbrod O, Zeevi D, Rothschild D, Leviatan S, Kosower N, Lotan-Pompan M, Weinberger A, Le Roy CI, Menni C, Visconti A, Falchi M, Spector TD, Adamski J, Franks PW, Pedersen O, Segal E · PubMed 33177712

  The serum metabolome contains a plethora of biomarkers and causative agents of various diseases, some of which are endogenously produced and some that have been taken up from the environment . The origins of specific compounds are known, including metabolites that are highly heritable , or those that are influenced by the gut microbiome , by lifestyle choices such as smoking , or by diet . However, the key determinants of most metabolites are still poorly understood. Here we measured the levels of 1,251 metabolites in serum samples from a unique and deeply phenotyped healthy human cohort of 491 individuals. We applied machine-learning algorithms to predict metabolite levels in held-out individuals on the basis of host genetics, gut microbiome, clinical parameters, diet, lifestyle and anthr

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