Expressive

rs119480069 - ABCG5

Magnitude 4.5 · 1 study on file

Reported associations

  • Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 36329257

    ABSTRACT: To explore the complex genetic architecture of common diseases and traits, we conducted comprehensive PheWAS of ten diseases and 34 quantitative traits in the community-based Taiwan Biobank (TWB). We identified 995 significantly associated loci with 135 novel loci specific to Taiwanese population. Further analyses highlighted the genetic pleiotropy of loci related to complex disease and associated quantitative traits. Extensive analysis on glycaemic phenotypes (T2D, fasting glucose and HbA1c) was performed and identified 115 significant loci with four novel genetic variants (HACL1, RAD21, ASH1L and GAK). Transcriptomics data also strengthen the relevancy of the findings to metabolic disorders, thus contributing to better understanding of pathogenesis. In addition, genetic risk sc

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Limit saturated fat intake Moderate

    Reducing dietary saturated fat can lower LDL cholesterol, beneficial for individuals with genetic predisposition to elevated LDL

    Reduce saturated fat to less than 7 percent of daily calories

Discuss with your doctor

  • Sitosterolemia risk and lipid management High

    This variant is pathogenic for sitosterolemia, a rare lipid absorption disorder affecting plant sterol metabolism

Exercise

  • Aerobic exercise program Moderate

    Aerobic exercise reduces LDL cholesterol and cardiovascular risk in individuals with genetic predisposition to elevated lipids

    Aim for at least 150 minutes of moderate aerobic activity per week

Screening

  • Monitor LDL cholesterol levels High

    This variant is strongly associated with elevated LDL cholesterol in genome-wide association studies

    Check lipid panel annually or per physician recommendation