rs11947802 - LINC02472; LINC02472; LINC02472

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for Acute Myeloid Leukemia - Oncotarget (2018) · Lv H, Zhang M, Shang Z, Li J, Zhang S, Lian D, Zhang R · PubMed 27903959

  ABSTRACT: Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, and generally considered to be caused by environment and genetic factors. In this study, we combined a genome-wide haplotype association study (GWHAS) and gene prioritization strategy to mine AML-related genetic affect factors and understand its pathogenesis. A total of 175 AML patients were downloaded from the public GEO database (GSE32462) and 218 matched Caucasian controls were from the HapMap Project. We first identified the linkage disequilibrium (LD) blocks and performed a GWHAS to scan AML-related haplotypes. Then we mapped these haplotypes to the corresponding genes as candidate. And finally, we prioritized all the AML candidate genes based on the similarity with 38 known AML susceptibility genes

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