Expressive

rs1194338 - LINC02736 - MALAT1

Magnitude 2.2 · 1 study on file

Reported associations

  • Translational genomics of osteoarthritis in 1,962,069 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 40205036

    ABSTRACT: Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including transcriptome, proteome and epigenome profiles of primary joint tiss

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Discuss genetic osteoarthritis risk stratification with physician Moderate

    Clinician can personalize screening intervals and prevention strategies based on individual risk modifiers

Exercise

  • Hip and core strengthening program Moderate

    Hip stability and strength reduce mechanical stress on joints predisposed to osteoarthritis

    3x/week, 30 minutes: hip abductor/extensor exercises and core stability training

Lifestyle

  • Maintain BMI below 25 kg/m2 Moderate

    Excess weight amplifies mechanical burden on genetically vulnerable hip joints

    Target BMI 18.5-24.9; gradual weight loss of 1-2 lbs/week if needed

Screening

  • Hip joint imaging screening for osteoarthritis Moderate

    Genetic variant strongly associates with hip osteoarthritis risk; early detection improves management outcomes

    Baseline imaging exam at age 40, repeat every 2-3 years