rs11941399 - Y_RNA - SPOCK3

Magnitude 2.0 · 1 study on file

Reported associations

• Identification of Novel Germline Polymorphisms Governing Capecitabine Sensitivity - Unknown journal (n.d.) · Unknown authors · PubMed 22864933

  ABSTRACT: BACKGROUND Capecitabine, an oral 5-fluorouracil (5-FU) prodrug, is widely used in the treatment of breast, colorectal, and gastric cancers. To guide selection of patients potentially at greatest benefit of experiencing antitumor efficacy, or, alternatively, of developing toxicities, identifying genomic predictors of capecitabine sensitivity could permit its more informed use. METHODS Our objective was to perform capecitabine sensitivity genome-wide association studies (GWAS) using 503 well-genotyped human cell lines from individuals representing multiple different world populations. Meta-analysis including all ethnic populations then enabled identification of novel germline determinants (SNPs) of capecitabine susceptibility. RESULTS First, intra-population GWAS of Caucasian indiv

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