rs11941209 - GABRB1
Magnitude 4.5 · 1 study on file
Reported associations
-
Genome-wide meta-analyses of cross substance use disorders in diverse populations - Unknown journal (n.d.) · Unknown authors · PubMed 41057643
ABSTRACT: Substance use disorders (SUDs, including alcohol, cannabis, opioids, and tobacco) represent significant public health challenges. The estimated heritability of SUDs is ~50% and many individuals experience multiple SUDs concurrently. Studies have demonstrated the existence of genes shared across multiple SUDs, and identifying these SUD-shared genes is critical to developing novel prevention and treatment strategies. Here, we conducted the largest cross SUD meta-analysis to date to identify SUD-shared genes using samples genetically similar to 1000 Genomes Project European (1kg-EUR-like), African (1kg-AFR-like), and American mixed (1kg-AMR-like) populations. We defined variants that had the same direction of effects across different SUDs (i.e., concordant variants) as SUD-shared. I
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
substance use disorder genetic risk Moderate
GABRB1 variant increases SUD risk through GABA-A receptor signaling alterations affecting reward and addiction pathways
Discuss genetic findings and appropriate prevention and early intervention strategies
Lifestyle
-
alcohol and recreational drug use Moderate
Genetic risk for SUD mediated through GABRB1; avoiding known substance abuse triggers reduces manifestation risk
Minimize alcohol consumption and strictly avoid recreational drugs
Screening
-
substance use disorder screening Moderate
Carriers of T allele at GABRB1 rs11941209 have significantly elevated genetic risk for substance use disorder
Baseline assessment and periodic screening for symptoms of SUD with healthcare provider