rs11940232 - LINC02172 - LINC00616

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study for multiple phenotype analysis - BMC proceedings (2020) · Deng X, Wang B, Fisher V, Peloso G, Cupples A, Liu CT · PubMed 30263053

  ABSTRACT: Genome-wide association studies often collect multiple phenotypes for complex diseases. Multivariate joint analyses have higher power to detect genetic variants compared with the marginal analysis of each phenotype and are also able to identify loci with pleiotropic effects. We extend the unified score-based association test to incorporate family structure, apply different approaches to analyze multiple traits in GAW20 real samples, and compare the results. Through simulation studies, we confirm that the Type I error rate of the pedigree-based unified score association test is appropriately controlled. In marginalanalysis of triglyceride levels, we found 1 subgenome-wide significant variant on chromosome 6. Joint analyses identified several suggestive genome-wide significant sign

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