rs11936387 - MAEA
Magnitude 2.2 · 1 study on file
Reported associations
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Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits - Unknown journal (n.d.) · Unknown authors · PubMed 40210677
ABSTRACT: Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with transcriptomic and proteomic measure using multi-omics data from a Hispanic/Latino population. Us
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Refined carbohydrates and added sugars Moderate
High glycemic load increases diabetes incidence; genetic risk increases susceptibility to postprandial glucose dysregulation
Limit refined grains, sugary beverages, processed foods to less than 10 percent of daily calories
Discuss with your doctor
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Personalized diabetes prevention strategy Moderate
Elevated genetic risk warrants individualized preventive plan to reduce incident diabetes
Exercise
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Regular aerobic exercise program Moderate
Physical activity reduces diabetes incidence; genetic risk warrants consistent aerobic training
150-300 minutes moderate-intensity aerobic activity per week
Screening
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Fasting glucose and HbA1c screening Moderate
rs11936387-C allele increases Type 2 diabetes risk; early detection enables preventive intervention
Annual fasting glucose and HbA1c testing starting at age 30