rs11933210 - IGBP1P5 - RN7SL101P

Magnitude 2.2 · 1 study on file

Reported associations

• Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder - Unknown journal (n.d.) · Unknown authors · PubMed 35181757

  ABSTRACT: UK Biobank (UKB) is a key contributor in mental health genome-wide association studies (GWAS) but only ~31% of participants completed the Mental Health Questionnaire ("MHQ responders"). We predicted generalized anxiety disorder (GAD), posttraumatic stress disorder (PTSD), and major depression symptoms using elastic net regression in the ~69% of UKB participants lacking MHQ data ("MHQ non-responders"; NTraining=50%; NTest=50%), maximizing the informative sample for these traits. MHQ responders were more likely to be female, from higher socioeconomic positions, and less anxious than non-responders. Genetic correlation of GAD and PTSD between MHQ responders and non-responders ranged from 0.636-1.08; both were predicted by polygenic scores generated from independent cohorts.

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