rs11933099 - RPL21P46 - SLIT2
Magnitude 2.2 · 1 study on file
Reported associations
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Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome - Unknown journal (n.d.) · Unknown authors · PubMed 39349817
ABSTRACT: Metabolic syndrome (MetS) is a complex hereditary condition comprising various metabolic traits as risk factors. Although the genetics of individual MetS components have been investigated actively through large-scale genome-wide association studies, the conjoint genetic architecture has not been fully elucidated. Here, we performed the largest multivariate genome-wide association study of MetS in Europe (nobserved = 4,947,860) by leveraging genetic correlation between MetS components. We identified 1,307 genetic loci associated with MetS that were enriched primarily in brain tissues. Using transcriptomic data, we identified 11 genes associated strongly with MetS. Our phenome-wide association and Mendelian randomization analyses highlighted associations of MetS with diverse di
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic predisposition to metabolic syndrome and prevention strategy Moderate
Variant-associated metabolic syndrome risk warrants personalized discussion of individual risk factors and prevention approaches
Screening
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Metabolic syndrome component screening Moderate
Genetic variant strongly associated with metabolic syndrome risk (p=5.00e-15, n=1.38M)
Annual fasting glucose, lipid panel, blood pressure, waist circumference assessment