rs1193237 - CAMTA1

Magnitude 2.2 · 1 study on file

Reported associations

• Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study - Unknown journal (n.d.) · Unknown authors · PubMed 31689377

  ABSTRACT: Background Smoking prevalence is higher amongst individuals with schizophrenia and depression compared with the general population. Mendelian randomisation (MR) can examine whether this association is causal using genetic variants identified in genome-wide association studies (GWAS). Methods We conducted two-sample MR to explore the bi-directional effects of smoking on schizophrenia and depression. For smoking behaviour, we used (1) smoking initiation GWAS from the GSCAN consortium and (2) we conducted our own GWAS of lifetime smoking behaviour (which captures smoking duration, heaviness and cessation) in a sample of 462690 individuals from the UK Biobank. We validated this instrument using positive control outcomes (e.g. lung cancer). For schizophrenia and depression we used GWA

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