rs11931264 - MARCHF1
Magnitude 4.5 · 1 study on file
Reported associations
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Genome‐Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β‐Blockers - Unknown journal (n.d.) · Unknown authors · PubMed 29478026
ABSTRACT: Background For many indications, the negative chronotropic effect of β‐blockers is important to their efficacy, yet the heart rate (HR) response to β‐blockers varies. Herein, we sought to use a genome‐wide association approach to identify novel single nucleotide polymorphisms (SNPs) associated with HR response to β‐blockers. Methods and Results We first performed 4 genome‐wide association analyses for HR response to atenolol (a β1‐adrenergic receptor blocker) as: (1) monotherapy or (2) add‐on therapy, in 426 whites and 273 blacks separately from the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) study. A meta‐analysis was then performed between the genome‐wide association analysis performed in PEAR atenolol monotherapy and add‐on therapy,
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Drug interactions
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atenolol or beta blocker dosing Moderate
This variant is associated with altered heart rate response to atenolol and beta blockers, suggesting potential differences in medication sensitivity.
Before starting atenolol, discuss this genetic finding with your doctor for potential dosage adjustment