rs11929677 - CLDN16
Magnitude 4.5 · 1 study on file
Reported associations
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Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas - Unknown journal (n.d.) · Unknown authors · PubMed 38714721
ABSTRACT: Adverse pregnancy outcomes (APOs) affect a large proportion of pregnancies and represent an important cause of morbidity and mortality worldwide. Yet the pathophysiology of APOs is poorly understood, limiting our ability to prevent and treat these conditions. To search for genetic markers of maternal risk for four APOs, we performed multi-ancestry genome-wide association studies (GWAS) for pregnancy loss, gestational length, gestational diabetes, and preeclampsia. We clustered participants by their genetic ancestry and focused our analyses on three sub-cohorts with the largest sample sizes: European, African, and Admixed American. Association tests were carried out separately for each sub-cohort and then meta-analyzed together. Two novel loci were significantly associated with an
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Weight management and regular physical activity Moderate
CLDN16 variant affects pancreatic tissue expression; metabolic optimization may reduce gestational diabetes risk
Target 150+ minutes moderate aerobic activity weekly and maintain BMI below 25 when possible
Screening
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Gestational diabetes screening in pregnancy Moderate
CLDN16 rs11929677 C allele associated with 2.0-fold increased gestational diabetes risk
Discuss with obstetrician about optimal screening timing and frequency