rs11925694 - IGF2BP2
Magnitude 2.2 · 1 study on file
Reported associations
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Genotyping and population characteristics of the China Kadoorie Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 37601966
ABSTRACT: Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of >512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across China. Detailed data from questionnaires and physical measurements were collected at baseline, with additional measurements at three resurveys involving ∼5% of surviving participants. Analyses of genome-wide genotyping, for >100,000 participants using custom-designed Axiom arrays, reveal extensive relatedness, recent consanguinity, and signatures reflecting large-scale population movements from recent Chinese history. Systematic genome-wide association studies of incident disease, captured through electronic linkage to death and disease registries and to the national health insurance system, replicate est
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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personalized diabetes prevention strategy Moderate
Carriers of the rs11925694-G allele have increased genetic risk for type 2 diabetes, warranting individualized prevention discussion.
Exercise
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regular moderate-intensity aerobic activity Moderate
Physical activity improves insulin sensitivity and glucose homeostasis, offsetting genetic predisposition to type 2 diabetes.
150 minutes of moderate-intensity aerobic exercise per week, or 75 minutes vigorous-intensity
Screening
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type 2 diabetes screening Moderate
rs11925694-G allele is associated with 1.138-fold increased type 2 diabetes risk through IGF2BP2 metabolic regulation.
screening every 2-3 years or per clinical guidelines; consider earlier screening if age 45+