rs11925209 - CFAP20DC-DT x HAVCR1

Magnitude 2.0 · 1 study on file

Reported associations

• Region-based interaction detection in genome-wide case-control studies - Unknown journal (n.d.) · Unknown authors · PubMed 31888606

  ABSTRACT: Background In genome-wide association study (GWAS), conventional interaction detection methods such as BOOST are mostly based on SNP-SNP interactions. Although single nucleotides are the building blocks of human genome, single nucleotide polymorphisms (SNPs) are not necessarily the smallest functional unit for complex phenotypes. Region-based strategies have been proved to be successful in studies aiming at marginal effects. Methods We propose a novel region-region interaction detection method named RRIntCC (region-region interaction detection for case-control studies). RRIntCC uses the correlations between individual SNP-SNP interactions based on linkage disequilibrium (LD) contrast test. Results Simulation experiments showed that our method can achieve a higher power than conve

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