rs11924650 - CACNA2D3
Magnitude 4.5 · 1 study on file
Reported associations
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Exploring genetic variants in obsessive compulsive disorder severity: A GWAS approach. - Journal of affective disorders (2021) · Alemany-Navarro M, Cruz R, Real E, Segalàs C, Bertolín S, Baenas I, Domènech L, Rabionet R, Carracedo Á, Menchón JM, Alonso P · PubMed 32063569
The severity of Obsessive-Compulsive Disorder (OCD) varies significantly among probands. No study has specifically investigated the genetic base of OCD severity. A previous study from our group found an OCD polygenic risk score to predict pre- and post-treatment severity. This study explores the genomic bases of OCD severity. We administered the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) to 401 patients at their first visit to our clinic to measure their OCD severity. Genotyping data was collected by using the Infinium PsychArray-24 BeadChip kit (Illumina). We analyzed genetic association with OCD severity in a linear regression analysis at single-nucleotide polymorphism (SNP)- and gene-levels, this last also considering rare variants. Enrichment analyses were performed from gene-based
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic association with OCD severity Moderate
CACNA2D3 rs11924650 shows GWAS association with OCD severity, suggesting genetic contribution to obsessive-compulsive disorder.
Mention this finding to your healthcare provider, particularly if concerned about OCD symptoms.
Screening
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OCD symptoms and patterns Moderate
Genetic association with OCD severity suggests increased risk for obsessive-compulsive symptoms.
Attend to intrusive thoughts or compulsions; discuss any concerns with a healthcare provider.